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doi: 10.3389/fphys.2025.1613917 Received 17 April 2025 Revised 30 September 2025 Accepted 07 October 2025 Published 20 November 2025 Corrected 27 November 2025 Volume 16 - 2025 Edited by Elena Di Pierro, IRCCS Ca Granda Foundation Maggiore Policlinico Hospital, Italy Reviewed by Tiago L Duarte, Universidade do Porto, Portugal Hans Bumler, Charit University Medicine Berlin, Germany Updates Copyright 2025 Rose, Moore, Eskew, Vanacore, Hartson, Province, Skaff and Smith

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Samples were acquired on an Aurora 5 L Flow cytometer (Cytek Biosciences), unmixing and spillover correction were performed on SpectroFlo (Cytek Biosciences), conventional FCS gating and clustering were performed in Flowjo 10.8.1 with Phenograph and UMAP plugins

Novo Nordisk will almost certainly launch with: A savings card for patients with commercial insurance (reducing costs to $25$50/month in many cases) A patient assistance program for income-qualifying uninsured patients Possible direct-to-consumer pricing through NovoCare Pharmacy, similar to Wegovys $349/month self-pay model